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Xun Hu Selected Research

shikonin

5/2018Shikonin, vitamin K3 and vitamin K5 inhibit multiple glycolytic enzymes in MCF-7 cells.
1/2013Anticancer agent shikonin is an incompetent inducer of cancer drug resistance.
2/2009Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance.
2/2008Bypassing cancer drug resistance by activating multiple death pathways--a proposal from the study of circumventing cancer drug resistance by induction of necroptosis.
9/2007Targeting the weak point of cancer by induction of necroptosis.
5/2007Shikonin circumvents cancer drug resistance by induction of a necroptotic death.

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Xun Hu Research Topics

Disease

44Neoplasms (Cancer)
04/2022 - 10/2004
14Schizophrenia (Dementia Praecox)
01/2022 - 08/2004
8Lung Neoplasms (Lung Cancer)
12/2021 - 01/2005
7Lactic Acidosis
01/2022 - 06/2012
6Dehydration (Water Stress)
08/2022 - 11/2011
6Adenocarcinoma of Lung
04/2022 - 11/2013
6Breast Neoplasms (Breast Cancer)
06/2021 - 01/2005
5Neoplasm Metastasis (Metastasis)
06/2021 - 01/2012
5Cardiotoxicity
01/2016 - 02/2006
5Colorectal Neoplasms (Colorectal Cancer)
01/2005 - 07/2004
4Inflammation (Inflammations)
01/2020 - 01/2016
3Hypoxia (Hypoxemia)
06/2021 - 01/2019
3Fibrosis (Cirrhosis)
01/2021 - 01/2018
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2020 - 01/2014
2AIDS-Related Complex (ARC)
01/2022 - 01/2021
2Hepatocellular Carcinoma (Hepatoma)
01/2022 - 01/2014
2Carcinogenesis
12/2021 - 01/2020
2Starvation
10/2021 - 04/2005
2Bipolar Disorder (Manic Depressive Psychosis)
01/2021 - 06/2014
2Infections
01/2020 - 01/2018
2Coronary Disease (Coronary Heart Disease)
01/2020 - 08/2019
2Psychotic Disorders (Schizoaffective Disorder)
01/2019 - 12/2004
2Cardiovascular Diseases (Cardiovascular Disease)
09/2018 - 01/2016
2Hyperglycemia
01/2018 - 04/2014
2Cataract (Cataracts)
10/2015 - 07/2015
2Alcoholism (Alcohol Abuse)
01/2013 - 03/2010
2Nasopharyngeal Carcinoma
08/2010 - 11/2005
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
04/2008 - 03/2008
2Anorexia Nervosa
08/2007 - 04/2005
2Leukemia
02/2007 - 01/2007
2Anorexia
04/2006 - 06/2004
2Body Weight (Weight, Body)
04/2005 - 06/2004
1Arthrogryposis renal dysfunction cholestasis syndrome
01/2022
1Necrosis
10/2021

Drug/Important Bio-Agent (IBA)

16Glucose (Dextrose)FDA LinkGeneric
01/2022 - 11/2011
11Proteins (Proteins, Gene)FDA Link
06/2021 - 12/2004
9Pharmaceutical PreparationsIBA
06/2017 - 10/2004
8EnzymesIBA
06/2021 - 01/2005
7Biomarkers (Surrogate Marker)IBA
01/2022 - 12/2004
7Antipsychotic Agents (Antipsychotics)IBA
01/2022 - 12/2018
7Lactic Acid (Lactate)FDA LinkGeneric
10/2021 - 06/2012
6MicroRNAs (MicroRNA)IBA
12/2021 - 11/2013
6shikoninIBA
05/2018 - 05/2007
6schizandrin BIBA
07/2013 - 02/2006
4Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 09/2007
4Blood Proteins (Serum Proteins)IBA
05/2012 - 07/2004
4Doxorubicin (Adriamycin)FDA LinkGeneric
01/2011 - 02/2006
4AnthracyclinesIBA
01/2011 - 09/2007
4Anti-Bacterial Agents (Antibiotics)IBA
01/2011 - 09/2007
4Member 1 Subfamily B ATP Binding Cassette TransporterIBA
11/2007 - 09/2005
4multidrug resistance-associated protein 1IBA
11/2007 - 01/2007
4honokiolIBA
05/2007 - 08/2004
3Bicarbonates (Hydrogen Carbonate)IBA
01/2022 - 01/2016
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2021 - 05/2007
3Tumor Biomarkers (Tumor Markers)IBA
01/2020 - 01/2005
3Triglycerides (Triacylglycerol)IBA
01/2020 - 08/2019
3Messenger RNA (mRNA)IBA
01/2019 - 11/2006
3diazonaphthalenedisulfonic acid (NDS)IBA
01/2019 - 08/2015
3Pyruvate KinaseIBA
05/2018 - 03/2012
3Hydrogen Sulfide (Sulfide, Hydrogen)IBA
11/2016 - 06/2014
3Brain-Derived Neurotrophic Factor (BDNF)IBA
09/2007 - 06/2004
2hydroxide ionIBA
08/2022 - 12/2021
2Histone DemethylasesIBA
04/2022 - 07/2021
2CalciumIBA
01/2022 - 01/2021
2Cisplatin (Platino)FDA LinkGeneric
12/2021 - 01/2008
2Serine (L-Serine)FDA Link
01/2021 - 01/2020
2erucylphosphocholineIBA
01/2021 - 01/2019
2phenethyl isothiocyanate (PEITC)IBA
01/2021 - 05/2014
2HDL CholesterolIBA
01/2020 - 01/2020
2oxidized low density lipoproteinIBA
01/2020 - 01/2020
2LDL CholesterolIBA
01/2020 - 01/2020
2LipidsIBA
01/2020 - 08/2019
2Dopamine (Intropin)FDA LinkGeneric
12/2019 - 04/2002
2Indicators and Reagents (Reagents)IBA
01/2019 - 01/2016
2CytokinesIBA
01/2019 - 01/2018
2Vitamin K 3 (Menadione)FDA Link
05/2018 - 03/2012
28- (4- carboxymethyloxy)phenyl- 1,3- dipropylxanthineIBA
01/2018 - 01/2018
2LanosterolIBA
10/2015 - 07/2015
2Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
02/2015 - 09/2007
2dibenzocyclooctadiene lignanIBA
07/2013 - 01/2012
25-hydroxymethylfurfural (hydroxymethylfurfural)IBA
04/2013 - 11/2011
2PolymersIBA
04/2013 - 11/2011
2DNA (Deoxyribonucleic Acid)IBA
01/2013 - 01/2006
2Furaldehyde (Furfural)IBA
08/2012 - 11/2011
2Cardiotonic Agents (Cardiac Stimulants)IBA
01/2011 - 11/2007
2Glutathione (Reduced Glutathione)IBA
01/2011 - 11/2007
2Vinca AlkaloidsIBA
02/2008 - 09/2007
2Proline Oxidase (Proline Dehydrogenase)IBA
09/2007 - 08/2004
2Methamphetamine (Desoxyn)FDA LinkGeneric
12/2004 - 08/2004
1biocharIBA
08/2022
1Gefitinib (Iressa)FDA Link
04/2022
1Circular RNAIBA
01/2022
1Glutathione Disulfide (GSSG)FDA LinkGeneric
10/2021
1NADP (NADPH)IBA
10/2021
1Glutamine (L-Glutamine)FDA Link
10/2021
1Paclitaxel (Taxol)FDA LinkGeneric
07/2021
1Cadherins (E-Cadherin)IBA
07/2021

Therapy/Procedure

11Therapeutics
12/2021 - 01/2013
8Drug Therapy (Chemotherapy)
01/2019 - 12/2004
6Lasers (Laser)
05/2012 - 12/2004